Phages are pretty cool, but bacteria do develop phage resistance as well. Phages also can evolve to evade those resistances, in a co-evolutionary battle, but also Phages can still be seen as antigens to our own body.

A recent case-study: https://www.upmc.com/media/news/021424-phage-therapy

To avoid reading the whole article: Antibiotics no-longer worked for a patient in 2020 that developed an infection after needing immunosuppression for treatment of an autoimmune condition, so they tried phage therapy.

quote from the phage treatment section:

Within 24 hours of receiving phage therapy, the patient’s blood infection had resolved and she could go home, where she continued the phage and antibiotic combination. She developed a few short-lived breakthrough infections, which indicated the bacteria was getting around the therapy, so the researchers found an additional phage that targeted her bacteria.

With the addition of the new phage, the patient was blood infection-free for four months and able to travel out of state for a for a family beach vacation.

However, just over six months after starting phage therapy, the blood infection returned, and the phage-antibiotic combination was thought to be no longer effective. The patient died in 2022.

In order to learn why the infections recurred despite the combination being previously effective, laboratory testing revealed that the patient’s immune system had likely activated in a way that blocked the phages from attacking the bacteria.

I’m not disagreeing with the benefits of Phage Therapy, just that it isn’t likely a magic solution all on it’s own, and can still suffer similar resistance issues as antibiotics have. I’m a fan of multipronged attack vectors, to reduce the chance of developing progressive resistances (ie. wipe out the whole colony), and the more tools we have for that, the better.

All I want to know is:

1. Can I watch Twitch streams on it?
2. Does it have a built in browser, I can watch videos from non-app services on?

I’ve been using roku for what feels like 15 to 20 years. I’m finally ready to buy an Apple TV just to be able to watch Twitch on it. If Google TV Streamer either has an official Twitch app, or can install normal android apps, like the Twitch app from the play store, and has a web browser that can play videos from standard websites, I am sold.

If someone has, or buys a streamer, please let me know with a reply.

national chain. I think it stored the transactions for transmission, and in-case it didn’t go through we also had the imprints as proof of having the card at the time of transaction. I assume it processed them as a different option instead of instant approval, and probably has different liability implications if the transaction is later denied. Being a big company, was probably fine.

Shop I worked for in 2005… I think … ran cards when the connection was down and took card impressions, and I think the transactions were all auto submitted when the connection came back up.

deleted by creator

I think this is a great time for remaining Reddit users to do a 3 month Reddit detox.

I have not kept up on antibiotic resistance research, or phages in recent years.

I do recall a number of years ago, I believe in the US, someone scooping up pond and garden soil samples looking for new phages.

A quick search though, does show work on “phagemids”; the following article does mention that phages can cause harm to the human host by releasing harmful toxins in the bacteria when cell lysis is performed (potentially causing sepsis, or death), as well as bacteria do also develop resistance to phages over time.

https://news.mit.edu/2015/engineered-particles-kill-harmful-bacteria-0625

They will, but there is also the chance that in gaining that new resistance, they may give up a different resistance, or become less lethal.

That’s the hopeful side of things; unfortunately, it is not uncommon for bacteria to develop resistance to a full combination of antibiotics over time, but I can be hopeful.

deleted by creator

deleted by creator

deleted by creator

deleted by creator